Structure of PDB 7yrg Chain L Binding Site BS01

Receptor Information
>7yrg Chain L (length=240) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTRQELKEVIE
RFKKDEHLEKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGA
KIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNC
AQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDG
FFGENNEFCECYTCERRGTGAFKSKYGLRETDKRLNRLKK
Ligand information
>7yrg Chain I (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaatatccacctgcagattctaccaaaagtgtatttggaaactgctcc
atcaaaaggcatgttcagcggaattccgctgaacatgccttttgatggag
cagtttccaaatacacttttggtagaatctgcaggtggatattgat
Receptor-Ligand Complex Structure
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PDB7yrg Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		R65 K258 R286
Binding residue
(residue number reindexed from 1)		R4 K148 R176
Enzymatic activity
Enzyme Commision number 2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7yrg, PDBe:7yrg, PDBj:7yrg
PDBsum7yrg
PubMed37536340
UniProtQ4FZB7|KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (Gene Name=KMT5B)

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