Structure of PDB 7xzx Chain L Binding Site BS01

Receptor Information
>7xzx Chain L (length=198) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPV
QLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQH
LIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCM
GGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRK
Ligand information
>7xzx Chain I (length=171) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ctatcgcgagccaggcctgagaatccggtgccgaggccgctcaattggtc
gtagacagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgt
tttaaccgccaaggggattactccctagtctccaggcacgtgtcagatat
agggcatgtccgggcatgtcc
Receptor-Ligand Complex Structure
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PDB7xzx Structural basis for p53 binding to its nucleosomal target DNA sequence.
Resolution4.53 Å
Binding residue
(original residue number in PDB)		K120 S121 R248
Binding residue
(residue number reindexed from 1)		K27 S28 R155
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xzx, PDBe:7xzx, PDBj:7xzx
PDBsum7xzx
PubMed36714865
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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