Structure of PDB 7v99 Chain L Binding Site BS01

Receptor Information
>7v99 Chain L (length=94) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLA
HYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK
Ligand information
>7v99 Chain R (length=243) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccauuuuuugucuaacccuaacugagaagggcguaggcgccgugcuuu
ugcuccccgcgcgcuguuuuucucgcugacuuucagcgggcggaaaagcc
ucggccugccgccuugagcaaacaaaaaaugucagcugcuggcccccgaa
ccccgccuggaggccgcggucggcccggggcuucuccggaggcacccacu
gccaccgcgaagaguugggcucugucagccgcgggucucucgg
<<<<<...........................<<<<<<<<.....<<<<<
<......<<<.<<<<<........(((((((((>>>>>.>>>.>>>>>>.
...>>>>>.>>>..............))).))))))...>>>>>.<<<<.
..<<<<.....<<<.<<<<<.<<<..<<<<<<<<....>>>>>.>>>...
>>>>>>>>..<<<<.....>>>>....>>>>>>>.....>>>>
Receptor-Ligand Complex Structure
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PDB7v99 Zipper head mechanism of telomere synthesis by human telomerase.
Resolution3.54 Å
Binding residue
(original residue number in PDB)		R33 Y42 K46 G53 I54 S56 M59
Binding residue
(residue number reindexed from 1)		R2 Y11 K15 G22 I23 S25 M28
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0019731 antibacterial humoral response
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular Component
GO:0000786 nucleosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7v99, PDBe:7v99, PDBj:7v99
PDBsum7v99
PubMed34782750
UniProtO60814|H2B1K_HUMAN Histone H2B type 1-K (Gene Name=H2BC12)

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