Structure of PDB 7u4d Chain L Binding Site BS01
Receptor Information
>7u4d Chain L (length=89) Species:
9606
(Homo sapiens) [
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GWLKEIRKLQKSTHLLIRKLPFSRLAREICVKFTRGVDFNWQAQALLALQ
EAAEAFLVHLFEDAYLLTLHAGRVTLFPKDVQLARRIRG
Ligand information
>7u4d Chain T (length=139) [
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gagaatccggtgccgaggccgctcaattggtcgtagacagctctagcacc
gcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggggat
tactccctagtctccaggcacgtgtcagatatatacatc
Receptor-Ligand Complex Structure
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PDB
7u4d
CENP-N promotes the compaction of centromeric chromatin.
Resolution
8.1 Å
Binding residue
(original residue number in PDB)
R72 N85 W86 A88 T120
Binding residue
(residue number reindexed from 1)
R27 N40 W41 A43 T75
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0003682
chromatin binding
GO:0005515
protein binding
GO:0030527
structural constituent of chromatin
GO:0046982
protein heterodimerization activity
Biological Process
GO:0000132
establishment of mitotic spindle orientation
GO:0000281
mitotic cytokinesis
GO:0034080
CENP-A containing chromatin assembly
GO:0051301
cell division
GO:0051382
kinetochore assembly
GO:0061644
protein localization to CENP-A containing chromatin
GO:0071459
protein localization to chromosome, centromeric region
Cellular Component
GO:0000775
chromosome, centromeric region
GO:0000779
condensed chromosome, centromeric region
GO:0000786
nucleosome
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005694
chromosome
GO:0005721
pericentric heterochromatin
GO:0005829
cytosol
GO:0043505
CENP-A containing nucleosome
GO:0061638
CENP-A containing chromatin
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:7u4d
,
PDBe:7u4d
,
PDBj:7u4d
PDBsum
7u4d
PubMed
35422519
UniProt
P49450
|CENPA_HUMAN Histone H3-like centromeric protein A (Gene Name=CENPA)
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