Structure of PDB 7tr8 Chain L Binding Site BS01

Receptor Information
>7tr8 Chain L (length=336) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MYVRISGRIRLNAHSLNAQGGGGTNYIEITKTKVTVRTENGWTVVEVPAI
TGNMLKHWHFVGFVDYFKTTPYGVNLTERALRYNGTRFGQGETTATKANG
ATVQLNDEATIIKELADADVHGFLAPKTGRRRVSLVKASFILPTEDFIKE
VEGERLITAIKHNRVDVDEKGAIGSSKEGTAQMLFSREYATGLYGFSIVL
DLGLVGIPQGLPVKFEENQPRPNIVIDPNERKARIESALKALIPMLSGYI
GANLARSFPVFKVEELVAIASEGPIPALVHGFYEDYIEANRSIIKNARAL
GFNIEVFTYNVDLGEDIEATKVSSVEELVANLVKMV
Ligand information
>7tr8 Chain R (length=45) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auugaaagagugcuuccccaaacccuuaacugguuguaacaguug
.............................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tr8 Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		N17 A18 Q19 G20 G22 N53 M54 G85 T86 L124 K161 N163 R164 V165 L184 F185 N253 R256
Binding residue
(residue number reindexed from 1)		N17 A18 Q19 G20 G22 N53 M54 G85 T86 L124 K161 N163 R164 V165 L184 F185 N253 R256
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Biological Process
External links
PDB RCSB:7tr8, PDBe:7tr8, PDBj:7tr8
PDBsum7tr8
PubMed35835111
UniProtQ8U333

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