Structure of PDB 7syk Chain L Binding Site BS01

Receptor Information
>7syk Chain L (length=96) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQ
SLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRR
Ligand information
>7syk Chain 2 (length=1697) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggau
gcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgc
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucuugggagcggccguccccugcucggcgccggcccgaagc
guuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgc
agcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucgga
acugaggccaugauuaagagggacggccgggggcauucguauugcgccgc
uagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauu
ugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagac
gaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugc
ggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaaguc
uuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuu
ggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaaca
cgggaaaccucacccggcccggacacggacaggauugacagauugauagc
ucuuucucgauuccgugggugguggugcauggccguucuuaguuggugga
gcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaac
uaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguu
cagccacccgagauugagcaauaacaggucugugaugcccuuagaugucc
ggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacg
ccggcaggcgcggguaacccguugaaccccauucgugauggggaucgggg
auugcaauuauuccccaugaacgaggaauucccaguaagugcgggucaua
agcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuac
uaccgauuggaugguuuagugaggcccucggaucggccccgccggggugc
ccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaagua
aaagucguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<...<....<<....<<..........>>...>>.>.......<<...
.....<<<.<....<<....<<<<.........<<.....<<.<<.....
..>>.>>......>>.........<<<<...<<<<<<....>>>>>>...
>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<
...>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....
<<<<<<<<<.<........>..>>>>>>.>>>......<<..<.......
....>..>>.........<<<<<((....<.<<<<.....<<..))>>..
.....>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<.....<<.<<<..>>>.>>..<<<<<..<<..>>.>>>.>>
..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>....
..>.>>>..>>>........<.<<.<<<<<<<...............>>>
>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<.
..<<<......>>>......>>>>>>>>..>>.......<<....>>...
>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<
<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<
<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.
....>>>.>.>.<<<......<<<......>>>....>>>..)))).]].
<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........
>>..........<<<<<......<<<<<<.......<<.<<<........
>>>.>>.....>>>>>>.<.<<.<<<.....<<<.......<<<.<<<<<
....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<.
.<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<...
..>>>>>........>>>........>>>.......>>>>>>......>>
>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<
<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<
<..........>>>>>>....>.....>>>>>.....<<<<<<<<.....
..>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<
<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<<<<<<<..>
>>>>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>
...>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
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PDB7syk Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		M1 K25 K47 Q50 S51 S54 F62
Binding residue
(residue number reindexed from 1)		M1 K25 K47 Q50 S51 S54 F62
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Cellular Component
GO:0005634 nucleus
GO:0022627 cytosolic small ribosomal subunit

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7syk, PDBe:7syk, PDBj:7syk
PDBsum7syk
PubMed35822879
UniProtG1TPV3

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