Structure of PDB 7sjp Chain L Binding Site BS01

Receptor Information

>7sjp Chain L (length=212) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISAT
SNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQG
TKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD
NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL
SSPVTKSFNRGE

Ligand information

>7sjp Chain E (length=11) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RKLPFSKREVP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7sjp Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	W90 W95
Binding residue (residue number reindexed from 1)	W90 W95

External links

PDB	RCSB:7sjp, PDBe:7sjp, PDBj:7sjp
PDBsum	7sjp
PubMed	36064790

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