Structure of PDB 7pnt Chain L Binding Site BS01

Receptor Information

>7pnt Chain L (length=176) Species: 10090 (Mus musculus)

KQDDEPPSSAFIKEYKDIIPNIEKVDDVVKRILSLEMASRKEKLKIKQEQ
LMNKIVENPEDSRTLEAQIIALTVRIRNYEEHMQKHRKDKAHKRHLLMSI
DRRKKLLKILRQTNYDVFEKTCKELGVEYTLPPLHFQKVHRRFLAKKALC
IRVYQEVQKLKKQKRALKAAAAAAKK

Ligand information

>7pnt Chain A (length=909)

aaagguuugguccuggccuuauaauuaauuagagguaaaauuacacaugc
aaaccuccauagaccgguguaaaaucccuuaaacauuuacuuaaaauuua
aggagaggguaucaagcacauuaaaauagcuuaagacaccuugccuagcc
acacccccacgggacucagcagugauaaauauuaagcaauaaacgaaagu
uugacuaaguuauaccucuuaggguugguaaauuucgugccagccaccgc
ggucauacgauuaacccaaacuaauuaucuucggcguaaaacgugucaac
uauaaauaaauaaauagaauuaaaauccaacuuauaugugaaaauucauu
guuaggaccuaaacucaauaacgaaaguaauucuagucauuuauaauaca
cgacagcuaagacccaaacugggauuagauaccccacuaugcuuagccau
aaaccuaaauaauuaaauuuaacaaaacuauuugccagagaacuacuagc
cauagcuuaaaacucaaaggacuuggcgguacuuuauauccaucuagagg
agccuguucuauaaucgauaaaccccgcucuaccucaccaucucuugcua
auucagccuauauaccgccaucuucagcaaacccuaaaaagguauuaaag
uaagcaaaagaaucaaacauaaaaacguuaggucaagguguagccaauga
aaugggaagaaaugggcuacauuuucuuauaaaagaacauuacuauaccc
uuuaugaaacuaaaggacuaaggaggauuuaguaguaaauuaagaauaga
gagcuuaauugaauugagcaaugaaguacgcacaccccuccuaaauuaaa
cuuaacauaauuaauuucuacguuuauggagauaaaagcauacugagugu
gcuuggaau

..((((..<<<<<<.)))).<<<<<<<.<..<<<<<<<<....<<<.<<<
..<......>......<<......<<<<<<<<<..<<<....>>>.>>>>
>>>.>>.<<<....<<...<<....>>..>>......>>>..<<...>>.
>>.<<<....>>>.....>>>>>>..........<<....<<<<....>>
>>..>>...>>.>>>>>>...<<<<<<<<.....(((.....((.>>>))
.......)))..>>>>>..>.>>>>>>>....<<<((.....<<<<....
<<............<<<<<<....<<<<<<<....<<......>>.....
>>>.>>>..>..........<<....>>.>>>>>>......>>....>>>
>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>...
.......<<<<.<<.......))..>>.>>>>.>>>.<<<.......<<<
....>>>.....>>>..>>>>>>.<<<<...<<<<........<<<<<..
<<<<<<<<<<.....<<........>>..........<<<<.<<......
.....<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>
>..>>......<<.....>>..........>>>...>>>>>>>>....>>
.>>>>..>>.>>>>>>>>.....<<<<<....>>>>>.....<<..<.<<
<<<<......>>>>>>..>.>>.....>>>>>.....<<<<<<<......
...>>>>>>>............>>>>..>>>.>....<<<<<<<<<....
......<<.....>>......>>>>>.>>>>....<<<<<<<<<.>>>>>
>>>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pnt Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
• Resolution: 3.19 Å
• Binding residue (original residue number in PDB): R101 R124 Q129 R136 N139 Y140 H143 H147 D150 K151 A152 H153 K154 R155 H156 L158 M159 D162 R163 K166 L167 K169 H196 F197 Q198 K199 H201 R202 R203 F204 K207 C211 Y215 R226
• Binding residue (residue number reindexed from 1): R40 R63 Q68 R75 N78 Y79 H82 H86 D89 K90 A91 H92 K93 R94 H95 L97 M98 D101 R102 K105 L106 K108 H135 F136 Q137 K138 H140 R141 R142 F143 K146 C150 Y154 R165

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005761 mitochondrial ribosome
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7pnt, PDBe:7pnt, PDBj:7pnt
• PDBsum: 7pnt
• PubMed: 35676484
• UniProt: Q9DC71|RT15_MOUSE Small ribosomal subunit protein uS15m (Gene Name=Mrps15)