Structure of PDB 7pir Chain L Binding Site BS01

Receptor Information

>7pir Chain L (length=118) Species: 272634 (Mycoplasmoides pneumoniae M129)

LGIDIPNQKRIEIALTYIFGIGLSRSQAILKQANINPDKRVKDLTEEEFV
AIRNVASAYKIEGDLRREIALNIKHLSEIGAWRGLRHRKNLPVRGQRTRT
NARTRKGPRKTVANKKIE

Ligand information

>7pir Chain 5 (length=1493)

ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaaua
caugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugagua
acacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuag
cuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugca
aggguucguuauuugaugagggugcgccauaucagcuaguugguggggua
acggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagcc
acaaugggacugagacacggcccauacuccuacgggaggcagcaguaggg
aauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgau
gaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuag
cagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaa
cuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggau
uuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaag
gcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugg
uagggaguuuuggaauuucauguggagcggugaaaugcguagauauauga
aggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuagg
cuugaaaguguggggagcaaauaggauuagauacccuaguaguccacacc
guaaacgauagauacuagcugucggggcgauccccucgguagugaaguua
acacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaa
acggaauugacggggacccgcacaagugguggagcauguugcuuaauucg
acgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuaug
gaaacauaaugccgagugacagguggugcaugguugucgucagcucgugu
cgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuagu
uacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggauga
cgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaaug
gccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguu
ggucucaguucggauugagggcugcaauucguccucaugaagucggaauc
acuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuu
guacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacgugu
ugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguu
aagucguaacaagguaccccuacgagaacguggggguggauca

.....<<<<..[.(((..>>>>..<<<.<<<<<...<<<<<<........
........<<..<<.<<<<<<....>>>>>>.>>>>.......<<.....
...<.<.<<<..<<........<<.<.<<.....<<<<<<....>>>>>>
......>>.>.....<<<<.............>.>>>....<<<<<<...
.>>>>>>.>>.......>>>>>.>.>.<<.....<<<..<<<<<<<<...
....>>>>>>>>>>>.......>>..<<<<<<<<....>>>...>>>>>.
>>.<<<<<............>>>>>.<<<<....>>>>............
......<<<....<<<<....>>>>..>>>...>.>>>>>...<<<<...
....<<<.....>>>......>>>>...<..<.<<........<<<<<<<
..........>>>>>>>.........>>>....>.....<<<<<(((...
<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>.....
......<<<(......<<<<...<<<.<<<<<<..<<<<<.<<<<.....
<<<<<<<.....>>>>>>>..>>>>.>>>..>>.>>>>>>...<<<.<<<
<...<<<<<<<....<<<<<<<<<..<<........>>.....>>>>>>>
>>...........<<....>>.>>>>>>>..>>>>..>>>...>>>...>
>>>....<<<<<<<.......<<<<.........>>>>....>>>>>>>.
.........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..
.)>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..
..))).]<<.<<.<<<<<<<.....<<<....<<<<<<<<<<......<<
........>>..........<<<<<<.........<<<<<....<<<.<<
....>>.>>>.>>>>>....<<<.<<<..<<<<<<.......<<<<<<<<
<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.
........>>>>>>>.....<<<<<....>>>>>........>>>>....
.....>>...>>>>>>>>>>....>>>>>>...>>.>>>>>>>>.....<
<<<<<......<<<..<<..<<<<....>>>>..>>....>>>.....>>
>>>>......<....<<<<<<<........>>>>>>>....>.......>
>>.....<<<<<<<..........>>>>>>>...........>>>>>>>>
>..>>....<..<<.<.<<<<.<....<<<<<<..<<<<.....<<<<<<
.<<<..<<....>>.>>>>>>>>>...>.>>>..>>>>>>....>.>>>>
..>.>>...>.....<<<<<<<<<....>>>>>>>>>......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pir Visualizing translation dynamics at atomic detail inside a bacterial cell.
• Resolution: 12.1 Å
• Binding residue (original residue number in PDB): K13 R14 I17 T20 Y21 I22 F23 G24 I25 G26 L27 S28 R29 K43 R44 I77 W86 R87 R90 H91 K93 L95 P96 V97 R98 G99 Q100 R101 T102 R103 T104 N105 R107 T108 R109 K110 P112 R113 K114 N118 K119 K120 I121
• Binding residue (residue number reindexed from 1): K9 R10 I13 T16 Y17 I18 F19 G20 I21 G22 L23 S24 R25 K39 R40 I73 W82 R83 R86 H87 K89 L91 P92 V93 R94 G95 Q96 R97 T98 R99 T100 N101 R103 T104 R105 K106 P108 R109 K110 N114 K115 K116 I117

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7pir, PDBe:7pir, PDBj:7pir
• PDBsum: 7pir
• PubMed: 36171285
• UniProt: Q50297|RS13_MYCPN Small ribosomal subunit protein uS13 (Gene Name=rpsM)