Structure of PDB 7ojk Chain L Binding Site BS01

Receptor Information
>7ojk Chain L (length=1843) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDDMACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCI
EIDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLIL
LECFVRSSPANFEQKYIEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNE
QIPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMTSGRLSGV
ESLNVLLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLR
KGEITGQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPILR
FLYANIGEGIKECQMQYWRSFLNKVKSLRILNTRRKLLLIFDALILLASI
HDQTRHKCSKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQQSERSPPD
KNQILISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDLILNFDV
SGVVPTISYQRTEDEKFPFIMGGVELLESTDLERLSSLSLALVNSMKTSS
TVKLRQNEFGPARYQVVRCKEAYCQEFLLSGAEFQLIYQKTGECSKCYAI
NDNRVGEICSFYADPKRYFPAIFSAEVLQTTVSTMISWVKDCSELEEQLC
NINSLTKMILVLILAHPSKRSQKLLQNLRYFIMAYVSDYHHKDLIDKLRE
ELITDVEFLLYRLVRALVNLILSEDVKSMMTNRFKFILNISYMCHFITKE
TPDRLTDQIKCFEKFLEPKLEFGHVSINPADVATEEELDDMVYNAKKFLS
KEGCTSIKGPDYKKPGVSKRFLSLLTSSFNNGSLFKESEVKREIKDPLVK
SVVVNKYTDGSRVLNYDFNKLTALAVSQLTEVFSRKGKHLLNKQDYDYKV
QQAMSNLVLGPADLDEILLDGGASVYFDQLKETVERIIDQYDQPSVNDLD
EVVPNKFYIRLIKGELSNHMVEDFDYDVLPGNFYEEFCDAVYKNNKLKER
YFYCGTKAVATRTYFDQEYFQCFKSILLIMNANNFKFDMGRLSDDVRISE
RESNSEALSKALSLTNCTTAMLKNLCFYSQESPQSYSSTGPDTGRLKFSL
SYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNEREFEN
AILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLATLQNLIFLSKDLQADI
KGRDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQLGLKKKTTQSITED
FFYSNFQIGVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISCICG
GTIDAYTSSDDQISLFDQVLTELMQRDPEEFKTLIEFHYYMSDQLNKFVS
PKSVIGRFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETID
TIIDQSVANGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNCETDVRDWVD
GNRSYRIMRQIERLIPDACGRIRSMLRKLYNKLKTGQLHEEFTTNYLSSE
HLSSLSNLCELLGVEPPSESDLEFSWLNLAAHHPLRMVSSIASGFVGLCR
TLGSKCVRGPNKESLYIKSIQSLISDIQGIEPLIDSHGVQYWRVPLNIRD
GNEGVISYFRPLLWDYMCISLSTAIELGAWVLGEPKKVRVLEFFKHNPCD
YFPLKPAAGLNHIIHSLRRLYPSVFEKHILPFMSDLASTKMKWSPRIKFL
DLCVALDVNCREEHYIVLSSELRLSHTRTHTSDAVDNFMRQIYFESYVRS
FVATTRTLGSFTWFPHKTSVPEGEGLQRLGPFSSFVEKAIHKGIERPMFK
HDLMPVPLVVHRSGLWECDKKLASFTPVVQDQDLEMFVKEVGDSSLDLLI
GALSAMILDRLKLRMQWSEVDIVSMLKAAMPSNSVKVLNAVLE
Ligand information
Receptor-Ligand Complex Structure
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PDB7ojk Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Resolution3.89 Å
Binding residue
(original residue number in PDB)		T341 R342 R343 R398 R399 K953
Binding residue
(residue number reindexed from 1)		T333 R334 R335 R390 R391 K906
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ojk, PDBe:7ojk, PDBj:7ojk
PDBsum7ojk
PubMed34857749
UniProtA0A3S8NV63

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