Structure of PDB 7oeb Chain L Binding Site BS01

Receptor Information
>7oeb Chain L (length=1434) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDDMACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCI
EIDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLIL
LECFVRSSPANFEQKYIEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNE
QIPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMSGVESLNV
LLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLRKGEIT
GQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPILRFLYAN
IGEKECQMQYWRSFLNKVKSLRILTRRKLLLIFDALILLASIHDQTRHKC
SKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQQSERSNTIQPPDKNQI
LISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDLILNFDVSGVV
PTISYQRTKFPFIMGGVELLESTDLERLSSLSLALVNSMKTSSTVQVVRC
KEAYCQEFLLSGAEFQLIYQKTGECSKCYAINDNRVGEICSFYADPKRYF
PAIFSAEVLQTTVSTMISWVKDCSELEEQLCNINSLTKMILVLILAHPSK
RSQKLLQNLRYFIMAYVSDYHHKDLIDKLREELITDVEFLLYRLVRALVN
LILSEDVKSMMTNRFKFILNISYMCHFITKETPDRLTDQIKCFEKFLEPK
LEFGHVSINPADVATEEELDDMVYNAKKFLSKEGCTSIKGPDYKKPGVSK
RFLSLLTSSFNNGSLFKESEVCTTAMLKNLCFYSQESPQSYSSTGPDTGR
LKFSLSYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNE
REFENAILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLATLQNLIFQADI
KGRDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQLGTTQSITEDFFYS
NFQIGVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISCICGGTID
AYTSSDDQISLFDQVLTELMQRDPEEFKTLIEFHYYMSDQLNKFVSPKSV
IGRFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETIDTIID
QSVANGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNCETDVRDWVDGNRS
YRIMRQIERLIPDACGRIRSMLRKLYNKLKTGQLHEEFTTNYLSSEHLSS
LSNLCELLGVEPPSESDLEFSWLNLAAHHPLRMVPTIVKTIQNKLSSTFT
RGAQKLLSEAINKSAFQSSIASGFVGLCRTLGSKCVRGPNKESLYIKSIQ
SLISDIQGIEPLIDSHGVQYWRVPLNIRDGNEGVISYFRPLLWDYMCISL
STAIELGAWVLGEPKKVRVLEFFKHNPCDYFPLKPAAIKFLDLCVALDVN
CEALSLVSHIVKKREEHYIVLSSELRLSHTRTHE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oeb Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Resolution3.04 Å
Binding residue
(original residue number in PDB)		S328 N331 K332 S335 N379 D380 S499 L502 K509 F585 S1446 Q1449 Y1450 R1452 R1622 G1625 S1626
Binding residue
(residue number reindexed from 1)		S313 N316 K317 S320 N363 D364 S480 L483 K490 F554 S1121 Q1124 Y1125 R1127 R1279 G1282 S1283
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oeb, PDBe:7oeb, PDBj:7oeb
PDBsum7oeb
PubMed34857749
UniProtA0A3S8NV63

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