Structure of PDB 7oe7 Chain L Binding Site BS01

Receptor Information
>7oe7 Chain L (length=1382) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVESLNVLLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNR
LRKGEITGQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPI
LRFLYANIGEGEERHHTIKECQMQYWRSFLNKVKSLRIRRKLLLIFDALI
LLASIHDQTRHKCSKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQQSE
RPPDKNQILISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDLIL
NFDVSGVVPTISYQRTEDEKFPFIMGGVELLESTDLERLSSLSLALVNSM
KTSSTCKEAYCQEFLLSGAEFQLIYQKTGECSKCYAINDNRVGEICSFYA
DPKRYFPAIFSAEVLQTTVSTMISWVKDCSELEEQLCNINSLTKMILVLI
LAHPSKRSQKLLQNLRYFIMAYVSDYHHKDLIDKLREELITDVEFLLYRL
VRALVNLILSEDVKSMMTNRFKFILNISYMCHFITKETPDRLTDQIKCFE
KFLEPKLEFGHVSINPADVATEEELDDMVYNAKKFLSKEGCTSIKGPDYK
KPGVSKRFLSLLTSSFNNGSLFKESEVKREIKDPLVTATALDLASNKSVV
VNKYTDGSRVLNYDFNKLTALAVSQLTEVFSRKGKHLLNKQDYDYKVQQA
MSNLVLGPLDGGASVYFDQLKETVERIIDQYNFKFDMGRLSDDVRISERE
SNSEALSKALSLTNCTTAMLKNLCFYSQESPQSYSSTGPDTGRLKFSLSY
KEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNEREFENAI
LSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLATLQNLIFLSKDLQADIKG
RDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQLGLKKKTTQSITEDFF
YSNFQIGVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISCICGGT
IDAYTSSDDQISLFDQVLTELMQRDPEEFKTLIEFHYYMSDQLNKFVSPK
SVIGRFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETIDTI
IDQSVANGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNCETDVRDWVDGN
RSYRIMRQIERLIPDACGRIRSMLRKLYNKLKTGQLHEEFTTNYLSSEHL
SSLSNLCELLGVEPPSESDLEFSWLNLAAHHPLRMVLPTIVKTIQNKLSS
TFTRGAQKLLSEAINKSSSIASGFVGLCRTLGSKCVRGPNKESLYIKSIQ
SLISDIQGIEPLIDSHGVQYWRVPLNIRDGNEGVISYFRPLLWDYMCISL
STAIELGAWVLGEPKKVRVLEFFKHNPCDYFPLKPAAIKFLDLCVALDVN
CEALSLVSHIVKREEHYIVLSSELRLSHTRTH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7oe7 Chain L Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oe7 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Resolution3.73 Å
Binding residue
(original residue number in PDB)		H316 H364
Binding residue
(residue number reindexed from 1)		H116 H161
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oe7, PDBe:7oe7, PDBj:7oe7
PDBsum7oe7
PubMed34857749
UniProtA0A3S8NV63

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