Structure of PDB 7oe3 Chain L Binding Site BS01

Receptor Information
>7oe3 Chain L (length=1478) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDDMACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCI
EIDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLIL
LECFVRSSPANFEQKYIEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNE
QIPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMTSGRLSGV
ESLNVLLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLR
KGEITGQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPILR
FLYANIGEGNGEERHHTIKECQMQYWRSFLNKVKSLRILNTRRKLLLIFD
ALILLASIHDQTRHKCSKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQ
QSEPPDKNQILISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDL
ILNFDVSGVVPTISYQDEKFPFIMGGVELLESTDLERLSSLSLALVNSMK
TSSTCKEAYCQEFLLSGAEFQLIYQKTGECSKCYAINDNRVGEICSFYAD
PKRYFPAIFSAEVLQTTVSTMISWVKDCSELEEQLCNINSLTKMILVLIL
AHPSKRSQKLLQNLRYFIMAYVSDYHHKDLIDKLREELITDVEFLLYRLV
RALVNLILSEDVKSMMTNRFKFILNISYMCHFITKETPDRLTDQIKCFEK
FLEPKLEFGHVSINPADVATEEELDDMVYNAKKFLSKEGCTSIKGPDYKK
PGVSKRFLSLLTSSFNNGSLFKESEVKRNCTTAMLKNLCFYSQESPQSYS
STGPDTGRLKFSLSYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQL
SGSCLNNEREFENAILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLATLQ
NLIFLSKDLQADIKGRDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQL
GTTQSITEDFFYSNFQIGVVPSHVSSILDMGQGILHNTSDFYALISERFI
NYAISCICGGTIDAYTSSDDQISLFDQVLTELMQRDPEEFKTLIEFHYYM
SDQLNKFVSPKSVIGRFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKE
PHQLAETIDTIIDQSVANGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNC
ETDVRDWVDGNRSYRIMRQIERLIPDACGRIRSMLRKLYNKLKTGQLHEE
FTTNYLSSEHLSSLSNLCELLGVEPPSESDLEFSWLNLAAHHPLRMVEKV
PTIVKTIQNKLSSTFTRGAQKLLSEAINKSAFQSSIASGFVGLCRTLGSK
CVRGPNKESLYIKSIQSLISDIQGIEPLIDSHGVQYWRVPLNIRDGNEGV
ISYFRPLLWDYMCISLSTAIELGAWVLGEPKKVRVLEFFKHNPCDYFPLK
PAARVGLNHIIHSLRRLYPSVFEKHILPFSPRIKFLDLCVALDVNCEALS
LVSHIVKREEHYIVLSSELRLSHTRTHE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7oe3 Chain L Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oe3 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		H316 H364 C366
Binding residue
(residue number reindexed from 1)		H316 H364 C366
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oe3, PDBe:7oe3, PDBj:7oe3
PDBsum7oe3
PubMed34857749
UniProtA0A3S8NV63

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