Structure of PDB 7nsp Chain L Binding Site BS01 |
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>7nsp Chain A (length=2903)
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gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgau gaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguu auaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuau cauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacau cuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcg agcgaacggggagcagcccagagccugaaucaguguguguguuaguggaa gcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaug cacaugcugugagcucgaugaguagggcgggacacgugguauccugucug aauauggggggaccauccuccaaggcuaaauacuccugacugaccgauag ugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagug aaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggc gugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguag caagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggc guuaaguugcaggguauagacccgaaacccggugaucuagccaugggcag guugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaa aaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccggga gauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucau cuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaa cccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacgg cgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcua aggucccaaagucaugguuaagugggaaacgaugugggaaggcccagaca gccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagc ucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugc accgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguuc uguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagug cgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccgg aagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccc cuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccu guacuugguguuacugcgaaggggggacggagaaggcuauguuggccggg cgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccg gaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaac aaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaauc guaccccaaaccgacacagguggucagguagagaauaccaaggcgcuuga gagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggaga aggcacgcugauauguaggugaggucccucgcggauggagcugaaaucag ucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugc aaacacgaaaguggacguauacggugugacgccugcccggugccggaagg uuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaa acggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggg uaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacc cgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggc aagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauug agccuugauguguaggauaggugggaggcuuugaaguguggacgccaguc ugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaac guugacccguaauccggguugcggacagugucugguggguaguuugacug gggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauc cuggucggacaucaggagguuagugcaauggcauaagccagcuugacugc gagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugg uucugaauggaagggccaucgcucaacggauaaaagguacuccggggaua acaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccu cgaugucggcucaucacauccuggggcugaaguaggucccaaggguaugg cuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugaga caguucggucccuaucugccgugggcgcuggagaacugaggggggcugcu ccuaguacgagaggaccggaguggacgcaucacugguguucggguuguca ugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaa gcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaa ggguccugaaggaacguugaagacgacgacguugauaggccgggugugua agcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaa ccu |
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PDB | 7nsp Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics. |
Resolution | 3.5 Å |
Binding residue (original residue number in PDB) | N4 E10 G11 S12 K13 K14 G16 K17 R18 L19 G20 R21 G22 G24 K29 T30 G32 R33 G34 H35 K36 Q38 K39 S40 R41 S42 G43 R47 R48 F50 G52 G53 Q54 M55 Y58 R59 R60 P62 K63 F64 G65 F66 R69 A71 E76 R78 N99 K109 I111 L112 T128 K129 |
Binding residue (residue number reindexed from 1) | N4 E10 G11 S12 K13 K14 G16 K17 R18 L19 G20 R21 G22 G24 K29 T30 G32 R33 G34 H35 K36 Q38 K39 S40 R41 S42 G43 R47 R48 F50 G52 G53 Q54 M55 Y58 R59 R60 P62 K63 F64 G65 F66 R69 A71 E76 R78 N99 K109 I111 L112 T128 K129 |
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Enzyme Commision number |
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