Structure of PDB 7ko4 Chain L Binding Site BS01

Receptor Information

>7ko4 Chain L (length=375) Species: 9823 (Sus scrofa)

DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQK
DSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEE
HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTG
IVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSF
VTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITI
GNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLS
TFQQMWITKQEYDEAGPSIVHRKCF

Ligand information

>7ko4 Chain Y (length=29) Species: 9823 (Sus scrofa)

MDAIKKKMQMLKLDKENALDRAEQAEADK

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ko4 The structure of the native cardiac thin filament at systolic Ca 2+ levels.
• Resolution: 8.0 Å
• Binding residue (original residue number in PDB): K326 P333
• Binding residue (residue number reindexed from 1): K326 P333

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0010628 positive regulation of gene expression
• GO:0030240 skeletal muscle thin filament assembly
• GO:0048741 skeletal muscle fiber development
• GO:0090131 mesenchyme migration

Cellular Component

• GO:0001725 stress fiber
• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005865 striated muscle thin filament
• GO:0005884 actin filament
• GO:0030027 lamellipodium
• GO:0030175 filopodium
• GO:0044297 cell body

External links

• PDB: RCSB:7ko4, PDBe:7ko4, PDBj:7ko4
• PDBsum: 7ko4
• PubMed: 33753506
• UniProt: P68137|ACTS_PIG Actin, alpha skeletal muscle (Gene Name=ACTA1)