Structure of PDB 7bg9 Chain L Binding Site BS01

Receptor Information

>7bg9 Chain L (length=82) Species: 9606 (Homo sapiens)

RSSRAGLQFPVGRVRRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELA
GNAARDNKKTRIIPRHLQLAIRNDEELNKLLG

Ligand information

>7bg9 Chain B (length=256)

gggugguggccauuuuuugucuaacccuaacugagaagggcguaggcgcc
gugcuuuugcuccccgcgcgcuguuuuucucgcugacuuucagcgggcgg
aaaagccucggccugccgccuuccgagcaaacaaaaaaugucagcugcug
gcccguucgccccgaaccccgccgaggccgcggucggcccggggcuucuc
cggaggcacccacugccaccgcgaagaguugggcucugucagccgcgggu
cucucg

.<<....<<<<<.........................<<<<<<<<<<...
..<<<<<<.....<<<<.<<<<<........(((((((((>>>>>.>>>>
>>>>>>....>>>>>.>>>>>..............))).))))))...>>
>>>......>>.<<<..<<<<<...<<..<<<<<.<<<..<<<<<<....
....>>>.>>>...>>>>>>>>..<<<<.....>>>>.....>>>>>>>.
...>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7bg9 Structure of human telomerase holoenzyme with bound telomeric DNA.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): R30 R78 R82
• Binding residue (residue number reindexed from 1): R13 R61 R65

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0019899 enzyme binding
• GO:0030527 structural constituent of chromatin
• GO:0031492 nucleosomal DNA binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0008150 biological_process
• GO:0031507 heterochromatin formation

Cellular Component

• GO:0000786 nucleosome
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:7bg9, PDBe:7bg9, PDBj:7bg9
• PDBsum: 7bg9
• PubMed: 33883742
• UniProt: P0C0S8|H2A1_HUMAN Histone H2A type 1 (Gene Name=H2AC11)