Structure of PDB 6vzg Chain L Binding Site BS01

Receptor Information
>6vzg Chain L (length=393) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLNRKCVVIHNGSHRTVAGFSNVELPQCIIPSSYIKRTEAEFIFGTYNMI
DAAAEKRNGDEVYTLVDSQGLPYNWDALEMQWRYLYDTQLKVSPEELPLV
ITMPATNGKPDMAILERYYELAFDKLNVPVFQIVIEPLAIALSMGKSSAF
VIDIGASGCNVTPIIDGIVVKNAVVRSKFGGDFLDFQVHERLAPLIKEEQ
KRSTDVWYEASTWIQQFKSTMLQVSEKDLFELERYYKEQADINNPLVQKK
NFLFKPLNKTLTLDLKECYQFAEYLFKPQLISDKFSPEDGLGPLMAKSVK
KAGASISPEQVYSLLLTNVIITGSTSLIEGMEQRIIKELSIRFPQYKLTT
FANQVMMDRKIQGWLGALTMANLPSWSLGKWYSKEDYETLKRD
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain6vzg Chain L Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vzg Structural insights into assembly and function of the RSC chromatin remodeling complex.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		G13 S14 H15 A161 Q229 K232 S233 S397 T398
Binding residue
(residue number reindexed from 1)		G12 S13 H14 A156 Q215 K218 S219 S324 T325
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003682 chromatin binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0006325 chromatin organization
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006368 transcription elongation by RNA polymerase II
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0016514 SWI/SNF complex
GO:0016586 RSC-type complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0043232 intracellular non-membrane-bounded organelle

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6vzg, PDBe:6vzg, PDBj:6vzg
PDBsum6vzg
PubMed33288924
UniProtQ12406|ARP7_YEAST Actin-related protein 7 (Gene Name=ARP7)

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