Structure of PDB 6r92 Chain L Binding Site BS01

Receptor Information
>6r92 Chain L (length=363) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPF
DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSIT
GLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVS
ASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLAT
ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS
EIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN
FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASA
MGYHILIWSQEEA
Ligand information
>6r92 Chain I (length=145) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaatatccacctgcagattctaccaaaagtgtatttggaaactgctcc
atcaaaaggcatgttcagctggttcagctgaacatgccttttgatggagc
agtttccaaatacacttttggtagaatctgcaggtggatattgat
Receptor-Ligand Complex Structure
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PDB6r92 DNA damage detection in nucleosomes involves DNA register shifting.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		R332 F334 Q335 H336 Y356 R370 G393 I394 Y413 H414
Binding residue
(residue number reindexed from 1)		R272 F274 Q275 H276 Y296 R310 G333 I334 Y353 H354
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006290 pyrimidine dimer repair
GO:0006974 DNA damage response
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0034644 cellular response to UV
GO:0051865 protein autoubiquitination
GO:0070914 UV-damage excision repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0030054 cell junction
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0032991 protein-containing complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r92, PDBe:6r92, PDBj:6r92
PDBsum6r92
PubMed31142837
UniProtQ92466|DDB2_HUMAN DNA damage-binding protein 2 (Gene Name=DDB2)

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