Structure of PDB 6r8y Chain L Binding Site BS01

Receptor Information
>6r8y Chain L (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRIL
QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG
AGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWF
CSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCC
DWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLL
TTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG
RYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMG
DTLASAMGYHILIWSQEEARTRK
Ligand information
>6r8y Chain I (length=145) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaatatccacctgcagattctaccaaaagtgtatttggaaactgctca
atcaaaaggcatgttcagctggttcagctgaacatgccttttgatggagc
agtttccaaatacacttttggtagaatctgcaggtggatattgat
Receptor-Ligand Complex Structure
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PDB6r8y DNA damage detection in nucleosomes involves DNA register shifting.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		R332 F334 Q335 Y356 G393 I394 Y413
Binding residue
(residue number reindexed from 1)		R278 F280 Q281 Y302 G339 I340 Y359
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006290 pyrimidine dimer repair
GO:0006974 DNA damage response
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0034644 cellular response to UV
GO:0051865 protein autoubiquitination
GO:0070914 UV-damage excision repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0030054 cell junction
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0032991 protein-containing complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r8y, PDBe:6r8y, PDBj:6r8y
PDBsum6r8y
PubMed31142837
UniProtQ92466|DDB2_HUMAN DNA damage-binding protein 2 (Gene Name=DDB2)

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