Structure of PDB 6oul Chain L Binding Site BS01

Receptor Information
>6oul Chain L (length=471) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPE
AITYLLEQYDRVEAEEARLSDLITGFVPELAREKFAELRAQYVVTRDTIK
ATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCV
EQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQ
KLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAK
KYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRS
IADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPED
KIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRA
ATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEA
KALRKLRHPSRSEVLRSFLDD
Ligand information
>6oul Chain P (length=61) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cacaaatccattgacaaaagaaggctaaaagggcatattccttttgaatt
gtccatataga
Receptor-Ligand Complex Structure
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PDB6oul E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R99 M102 M105 L110 R385 K392 K418 E420 R423 Y425 K426 S428 T429 Y430 T432 W433 R436 Q437 R451 P453 H455 T583 R586
Binding residue
(residue number reindexed from 1)		R10 M13 M16 L21 R243 K250 K276 E278 R281 Y283 K284 S286 T287 Y288 T290 W291 R294 Q295 R309 P311 H313 T441 R444
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6oul, PDBe:6oul, PDBj:6oul
PDBsum6oul
PubMed31841111
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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