Structure of PDB 6fec Chain L Binding Site BS01

Receptor Information
>6fec Chain L (length=137) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKR
AGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDN
KLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRR
Ligand information
>6fec Chain A (length=1776) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaa
cugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugu
gugggaugcgugcauuuaucagaucaaaaccaacccggucagcggcggcg
gcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcgg
cgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccg
ugccuaccauggugaccacgggugacggggaaucaggguucgauuccgga
gagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgc
aaauuacccacucccgacccggggagguagugacgaaaaauaacaauaca
ggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuua
acgaggauccauuggagggcaagucuggucgcagcagccgcgguaauucc
agcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguug
gaucuugagggcccgccccucggcgcccccucgaugugucccgcggggcc
cgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccg
ccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuug
uugguuuucggaacugaggccaugauuaagagggacggccgggggcauuc
guauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccag
agcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgg
agguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugcc
gacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgg
gaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaac
uuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaa
uuugacucaacacgggaaaccucacccggcccggacacggacaggauuga
cagauugauagcucuuucucgauucugugggugguggugcauggccguuc
uuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacuc
uggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacu
ucuuagagggacaaguggcguucagccacccgagauugagcaauaacagg
ucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggc
ucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccc
cauucgugauggggaucggggauugcaauuauuccccaugaacgaggaau
ucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuu
guacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccuc
ggaucggcccgccggggucggcccacggcccuggcggagcgcugagaaga
cggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccg
uaggugaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[.((((((................[[[.
[[[...<....<.....<<..........>>....>.>.......{{...
.....[[[.{..........[[[[[..................<<.....
<<..<.......>..>>......>>..........<<...<<........
..>>...>>..[[..(((((.......<<<<<<<<<<.<........>>>
>..............)))))......]]...<<<...<<......>>...
>>>.]].]]].......}.]]].<<<....<<<.....<<<<<<......
...>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.}
}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]]....
.....<<<....<<<.....>>>..>>>...............<<<.<<<
<<.<<<....>>>.>.>>>>..>>>......<..................
.>.........<<<<<((......<<<<.........)).........>>
>>.>>>>>..)))))).]]]............<<.......{{...[[[.
[[....<.<..>.>..........<<<<<...............>>>>>.
........<<<<<..........<<..............<<<.......>
>>....>>.........>>..>>>.......[[....[.(((((.....>
>>>>>>...))))).]...]]....]]....<<<<<<..<...<<<<..<
<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>......
.<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<
.....<...<<.............>>...>..>>>>>..........<<<
.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<
..>>>>...>>.....>>>......<<......<<<......>>>....>
>...]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<....
..<<........>>..........<<<<<.......<<<<<.......<<
.<<<........>>>.>>.....>>>>>....<..<<<....<<<<<<..
...<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<
.......<<<<..<<<<.......<..<<<....>>>>........>>>>
..>>>>........<<<<<.....>>>>>........>>>.....>>.>>
>...>...>>>.>......>>>>>...>>.>>>>.>>>.....<<.<<<.
.......<.......<<<.<<<<....>>>>.>>>....>.........>
>>.>>..........<.<<<<<..........>>>>>>..........>>
>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>
>>.>>.......<<.....<<<.<<....<<<<<<<<.<<...<<<<..<
...<<<<<<<<<<<<<<...........>>>>>>>>>...>>>>>...>.
.>>>>...>>.>>>>>>>>...>>.>>>......>>.........<<<<<
<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fec Structure of a human cap-dependent 48S translation pre-initiation complex.
Resolution6.3 Å
Binding residue
(original residue number in PDB)
R23 R24 K25 F28 K34 G35 V36 G37 R38 R39 Y40 T53 R55 W82 F83 L84 N85 R86 Q87 K88 V90 L103 L107 D110 H120 R121 L129 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 G140 R141 R142
Binding residue
(residue number reindexed from 1)
R18 R19 K20 F23 K29 G30 V31 G32 R33 R34 Y35 T48 R50 W77 F78 L79 N80 R81 Q82 K83 V85 L98 L102 D105 H115 R116 L124 R125 V126 R127 G128 Q129 H130 T131 K132 T133 T134 G135 R136 R137
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6fec, PDBe:6fec, PDBj:6fec
PDBsum6fec
PubMed29401259
UniProtP62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)

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