Structure of PDB 6c23 Chain L Binding Site BS01

Receptor Information

>6c23 Chain L (length=362) Species: 9606 (Homo sapiens)

YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQ
GEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT
MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF
GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD
YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV
CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL
GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC
DDASIWRWDRLR

Ligand information

>6c23 Chain B (length=13) Species: 9606 (Homo sapiens)

KRPRLQAQRKFAQ

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6c23 Structures of human PRC2 with its cofactors AEBP2 and JARID2.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): F97 N307 Y308 C324 I363 W364 Y365 R414
• Binding residue (residue number reindexed from 1): F18 N228 Y229 C245 I284 W285 Y286 R335

Gene Ontology

Molecular Function

• GO:0001222 transcription corepressor binding
• GO:0003682 chromatin binding
• GO:0005515 protein binding
• GO:0008047 enzyme activator activity
• GO:0031491 nucleosome binding
• GO:0042802 identical protein binding

Biological Process

• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0006325 chromatin organization
• GO:0021510 spinal cord development
• GO:0031507 heterochromatin formation
• GO:0045892 negative regulation of DNA-templated transcription

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0005829 cytosol
• GO:0035098 ESC/E(Z) complex

External links

• PDB: RCSB:6c23, PDBe:6c23, PDBj:6c23
• PDBsum: 6c23
• PubMed: 29348366
• UniProt: O75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)