Structure of PDB 5mqf Chain L Binding Site BS01

Receptor Information
>5mqf Chain L (length=336) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIK
KTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQ
RDDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRE
LRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFR
KLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLRLEINRGHMTTEAKR
AAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHE
DSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEK
Ligand information
>5mqf Chain 6 (length=89) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugcucgcuucggcagcacauauacuaaacgauacagagaagauuagcau
ggccccugcgcaaggaugacacgcaaauucgugaagcgu
<<<<<.<<....>>>>>>>..............................<
<...<<<.....>>>....>>..................
Receptor-Ligand Complex Structure
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PDB5mqf Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Resolution5.9 Å
Binding residue
(original residue number in PDB)		Y26 Q30 R33 S36 T162 N211
Binding residue
(residue number reindexed from 1)		Y17 Q21 R24 S27 T122 N171
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0071987 WD40-repeat domain binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0000398 mRNA splicing, via spliceosome
GO:0006281 DNA repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005662 DNA replication factor A complex
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mqf, PDBe:5mqf, PDBj:5mqf
PDBsum5mqf
PubMed28076346
UniProtQ99459|CDC5L_HUMAN Cell division cycle 5-like protein (Gene Name=CDC5L)

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