Structure of PDB 5iwa Chain L Binding Site BS01

Receptor Information
>5iwa Chain L (length=124) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRK
VAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGV
YDAAGVKDRKKSRSKYGTKKPKEA
Ligand information
>5iwa Chain A (length=1509) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaauuggagaguuugauccuggcucagggugaacgcuggcggcgugccua
agacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcg
gacgggugaguaacgcgugggugaccuacccggaagagggggacaacccg
gggaaacucgggcuaaucccccauguggacccgccccuuggggugugucc
aaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugg
ugggguaauggcccaccaaggcgacgacggguagccggucugagaggaug
gccggccacaggggcacugagacacgggccccacuccuacgggaggcagc
aguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuu
ggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccc
ccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgug
ccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugg
gcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacgg
cucaaccgugggggagcgugggauacgcucaggcuagacggugggagagg
gugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaac
gccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaa
agcguggggagcaaaccggauuagauacccggguaguccacgcccuaaac
gaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaa
gcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauuga
cgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcg
aagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugg
ggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucag
cucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgc
cguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaa
agcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccu
gggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaa
cggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaa
cccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccg
cggugaauacguucccgggccuuguacacaccgcccgucacgccauggga
gcgggcucuacccgaagucgccgggagccuacgggcaggcgccgagggua
gggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggug
cggcuggau
........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<.
.<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>.
.....<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<
<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>
>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<
<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>.
..>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>
>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..
<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<
<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<..
...<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<
<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<
.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<
<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>....
.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...
.<<<<<<...<<...<<<<.........>>>>...>>>>>>>>.......
...<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....
>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<
<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>
..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>
>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<
<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<
<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<...
.>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>
>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....
>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<.....
...>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>
>>>>......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<...
<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>
>>>>>>>>...>>.>>>>....>>...>.....<<<<<<<<<....>>>>
>>>>>....
Receptor-Ligand Complex Structure
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PDB5iwa Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.
Resolution3.5 Å
Binding residue
(original residue number in PDB)
P5 T6 N8 Q9 R12 K13 R15 E16 K17 K21 K23 V24 A30 P31 F32 R33 R34 K46 K47 N49 S50 R53 K54 Y69 G72 E73 G74 R86 G87 V90 K91 D92 P94 R97 V104 R113 K114 K115 S116 R117 S118 K119 G121 T122 K123 K124
Binding residue
(residue number reindexed from 1)
P1 T2 N4 Q5 R8 K9 R11 E12 K13 K17 K19 V20 A26 P27 F28 R29 R30 K42 K43 N45 S46 R49 K50 Y65 G68 E69 G70 R82 G83 V86 K87 D88 P90 R93 V100 R109 K110 K111 S112 R113 S114 K115 G117 T118 K119 K120
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5iwa, PDBe:5iwa, PDBj:5iwa
PDBsum5iwa
PubMed27071098
UniProtQ5SHN3|RS12_THET8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)

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