Structure of PDB 4u67 Chain L Binding Site BS01

Receptor Information

>4u67 Chain L (length=104) Species: 243230 (Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539)

RRKLRTRRKVRTTTAASGRLRLSVYRSSKHIYAQIIDDSRGQTLAAASSA
ALKSGNKTDTAAAVGKALAAAAAEKGIKQVVFDRGSYKYHGRVKALADAA
REGG

Ligand information

>4u67 Chain X (length=2667)

ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaauc
aagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguagg
cgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggacca
ccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugag
ggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccg
uggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauu
gaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaa
cggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucggg
cuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccggg
gggcggaggaccgaaccggugccugcugaaacagucucggaugaguugug
uuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaa
auguauugagguacagccucggauguugaccauguccuguagagcacuca
caaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccggga
gugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagac
caucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucguc
gcauagacagccaggagguuggcuuagaagcagccaccaagagugcguaa
uagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagug
aucuaccgaagcuauggauucaacucgccgaguugucugguaggggagcg
uucaguccgcggagaagccauaccggaaggagugguggagccgacugaag
ugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgcc
guaaggacaaggguuccuggggaagggucguccgcccagggaaagucggg
accuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuc
cugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugc
caagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaa
aucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaa
guuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugau
ugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggc
gcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuuc
ggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccagg
cgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacgua
uagggugugacgccugcccggugccggaaggucaaguggagcggugcaag
cugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucg
gguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaa
cgagggacucggugaaauugaauuggcuguaaagaugcggccuacccgua
gcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauu
cggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggac
cgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacg
gaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgc
aaagguagaagguggcuugacugcgagacugacacgucgagcagggagga
aacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaa
cggauaaaaguuaccccggggauaacaggcugaucucccccgagagucca
uaucggcggggagguuuggcaccucgaugucggcucgucgcauccugggg
cugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcg
agcuggguucagaacgucgugagacaguucggucucuauccgcuacgggc
gcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaac
ggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcua
uguccggaacggauaaccgcugaaagcaucuaagcgggaagccagcccca
agaugaguucucccacugcagguaagacucccggaagaccaccggguuaa
gaggccaggcgugcacgcauagcaauguguucagcggacuggugcucauc
agucgaggucuugacca

<<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<....
..<<<<<<.((..((.>>>.....<<<<<<...<<.))..))..>>....
..>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....
>>>>>>...<<<<<<.....<......>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<.....
..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>
>........<<<<<<<<.........>>>>>>>>......<<<<<..(((
(>>>>>..>>>......>>.>>>>>>.>>..............<<....>
>....>>.........<<<<....>>>>.............>....>>>>
>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<...
.....>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>
>...>>>...<<....>>...<<......>>.........>>>>>>>>>>
>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<.>>
>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>
>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<...
.<<<<<....>>>>><<<<<<<<<...<<<..<<<<<<...<<<...<<<
.<<<<......>>>>.>>>..>>.>...>>>>>>...>>>..>>>>>>>.
>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<
<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<
<........<<<<<......<<<<.......>>>>.........<<....
..>>...>>>>>....>>>>>>>>>.>>..........)))......>>>
>>>.>>>...>>>>>>><..<<<<<<...>>>>>>..>....>>>>>><.
<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>.
.>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<
....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<
.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>
>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<
<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<...
..>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>...
.>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>
>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>
>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..
>......>>>>><<<<<<<<...>>>>>>>>............<<<<<<<
<<..<<...........>>..<<<<<<<.....<<<.....>>>......
.>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>
>>>>...>>...>>>>>>>>..>>>>........<...........<<<<
<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>
>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<
<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<
<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<.......>.>>>>>...
.>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>
>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<..
.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<..
..>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.....
........>>>>..>>>>>>.......<<<<...<<<<<<...<<.....
..>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<
<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>..
.>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>.
...<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<
<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>
.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.
......>>>>>>>..<<..>>....<<<<<<<<<.......>>>>>....
<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...
>>>>....>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4u67 The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel.
• Resolution: 3.65 Å
• Binding residue (original residue number in PDB): K10 L11 T13 R14 R15 V17 R18 R26 V88 F89 R91 Y96
• Binding residue (residue number reindexed from 1): K3 L4 T6 R7 R8 V10 R11 R19 V81 F82 R84 Y89

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4u67, PDBe:4u67, PDBj:4u67
• PDBsum: 4u67
• PubMed: 28689968
• UniProt: Q9RSL2|RL18_DEIRA Large ribosomal subunit protein uL18 (Gene Name=rplR)