Structure of PDB 3vd0 Chain L Binding Site BS01

Receptor Information

>3vd0 Chain L (length=201) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HEFIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPI
QIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPA
SHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSS
CVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYRE
Q

Ligand information

>3vd0 Chain P (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

caggcatgcctg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3vd0 Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
Resolution	2.95 Å
Binding residue (original residue number in PDB)	N259 S261 R268 R293 C295 A296 R300
Binding residue (residue number reindexed from 1)	N148 S150 R157 R182 C184 A185 R189

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:3vd0, PDBe:3vd0, PDBj:3vd0
PDBsum	3vd0
PubMed	22474346
UniProt	O15350\|P73_HUMAN Tumor protein p73 (Gene Name=TP73)

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