Structure of PDB 2c4r Chain L Binding Site BS01

Receptor Information
>2c4r Chain L (length=491) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHIEGRHMKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYK
GKITRIEPSLEAAFVDYGAERHGFLPLKEIAREYFPNIKDVLREGQEVIV
QIDKEERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIELKEALASL
ELPEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIH
QESNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSSKIKL
YTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALTAIDINSAR
GDIEETAFNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQRAVENR
LREAVRQDRARIQISHISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGT
VRDNESLSLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAVNAI
ETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTLSYMLP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2c4r Structure of E. Coli Rnase E Catalytic Domain and Implications for RNA Processing and Turnover
Resolution3.6 Å
Binding residue
(original residue number in PDB)		F57 F67 K112 G113 S121 V128 G137 G138 I139 S140 R141 I167 R169 T170 Q390 R391
Binding residue
(residue number reindexed from 1)		F64 F74 K110 G111 S119 V126 G135 G136 I137 S138 R139 I159 R161 T162 Q378 R379
Enzymatic activity
Enzyme Commision number 3.1.26.12: ribonuclease E.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:2c4r, PDBe:2c4r, PDBj:2c4r
PDBsum2c4r
PubMed16237448
UniProtP21513|RNE_ECOLI Ribonuclease E (Gene Name=rne)

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