Structure of PDB 1p7h Chain L Binding Site BS01

Receptor Information
>1p7h Chain L (length=286) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPV
VQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKI
VGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRV
RLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYG
GQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEI
PEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1p7h Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Y424 T426 E427 K520 R522 N523 R537 K538
Binding residue
(residue number reindexed from 1)		Y32 T34 E35 K128 R130 N131 R145 K146
Binding affinityPDBbind-CN: Kd=20nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1p7h, PDBe:1p7h, PDBj:1p7h
PDBsum1p7h
PubMed12949493
UniProtQ13469|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

[Back to BioLiP]