Structure of PDB 1cwd Chain L Binding Site BS01
Receptor Information
>1cwd Chain L (length=98) Species:
9606
(Homo sapiens) [
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GSWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ
GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSR
Ligand information
>1cwd Chain P (length=8) [
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EGDFEEVL
Receptor-Ligand Complex Structure
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PDB
1cwd
The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
Resolution
2.25 Å
Binding residue
(original residue number in PDB)
R12 R32 S42 K57 H58 Y59 R74 G93
Binding residue
(residue number reindexed from 1)
R10 R30 S40 K55 H56 Y57 R72 G91
Enzymatic activity
Enzyme Commision number
2.7.10.2
: non-specific protein-tyrosine kinase.
External links
PDB
RCSB:1cwd
,
PDBe:1cwd
,
PDBj:1cwd
PDBsum
1cwd
PubMed
7532720
UniProt
P06239
|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)
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