Structure of PDB 8wh5 Chain K Binding Site BS01

Receptor Information
>8wh5 Chain K (length=445) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGQLKSYQLKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLSHLKGNG
LDGPYLVIAPLSTLSNWFNEIARFTPSINAIIYHGDKNQRDELRRKHMPK
TVGPKFPIVITSYEVAMNDAKRILRHYPWKYVVIDEGHRLKNHKCKLLRE
LKHLKMDNKLLLTGTPLQNNLSELWSLLNFILPDIQVVSKLHGILRPFIL
RRMKCDVELSLPRKKEIIMYATMTDHQKKFQEHLVNNTLEAHLGENAIRG
QGWKGKLNNLVIQLRKNCNHPDLLQGQIDGSYLYPPVEEIVGQCGKFRLL
ERLLVRLFANNHKVLIFSQWTKLLDIMDYYFSEKGFEVCRIDGSVKLDER
RRQIKDFSDEKSSCSIFLLSTRAGGLGINLTAADTCILYDSDWNPQMDLQ
AMDRCHRIGQTKPVHVYRLSTAQSIETRVLKRAYSKLKLEHVVIG
Ligand information
>8wh5 Chain I (length=133) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcgagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgtttaaccgcccaaggg
gattactccctagtctccaggcacgtgtcagat
Receptor-Ligand Complex Structure
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PDB8wh5 Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation.
Resolution3.58 Å
Binding residue
(original residue number in PDB)		C343 K344 N367 W622 R661 K665
Binding residue
(residue number reindexed from 1)		C145 K146 N169 W393 R432 K436
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006346 DNA methylation-dependent heterochromatin formation
GO:0009294 DNA-mediated transformation
GO:0031507 heterochromatin formation
GO:0032197 retrotransposition
GO:0032508 DNA duplex unwinding
GO:0040029 epigenetic regulation of gene expression
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wh5, PDBe:8wh5, PDBj:8wh5
PDBsum8wh5
PubMed38413824
UniProtQ9XFH4|DDM1_ARATH ATP-dependent DNA helicase DDM1 (Gene Name=DDM1)

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