Structure of PDB 8w1o Chain K Binding Site BS01

Receptor Information
>8w1o Chain K (length=1290) Species: 10905 (Bluetongue virus (serotype 1 / isolate South Africa)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VAITVQGAQLIKRVVERFYPGIAFNINEGACYIYKFSDHIRRIRMKHGTK
YRRQAEEIIRNISLRKERLYGIPVLDEVEWKYVFDGQTFQSYAFEVYVNS
ILPWSELDPEEEFLRNYRVSREMTEVEKFIEFRAKNEMQIYGDIPIKVWC
CFINELSAELKHVPLGMQVMADFVNRFDSPFHQGNRDLSNLEDFQVAYTT
PLLFEMCCMESILEFNIKMRMREEEISALEFGDMKVDPVGLLREFFILCL
PHPKKINNVLRAPYSWFVKMWGVGADPIVVLQSTAGDDRNSKDVFYDKFR
TEPNRYKALFRSSFYNESRRMNEEKILEAVKYSQKLGSHDRRLPLFEKML
KTVYTTPFYPHKSSNMILASFLLSIQTITGYGRAWVKNVSTEFDKQLKPN
PSNLVQDVSDLTREFFKQAYVEAKERREEIVKPEDLYTSMLRLTSSGFST
EIYVKKRFLIKINSRIKALVIFTKGHTVFTDEELHKKYNSVELYQTKGSR
DVPIKATRTIYSINLSVLVPQLIVTLPLNEYFSRVGGITSPDYKKIGGKV
IVGDLEATGSRVMDAADCFRNSADRDIFTIAIDYSEYDTHLTRHNFRTGM
LQGIREAMAPYRDLRYEGYTLEQIIDFGYGEGRVANTLWNGKRRLFKTTF
DAYIRLDESERDKGSFKVPKGVLPVSSVDVANRIAVDKGFDTLIAATDGS
DLALIDTHLSGENSTLIANSMHNMAIGTLMQREVGREQPGVLTFLSEQYV
GDDTLFYTKLHTTDTKVFDKVAASIFDTVAKCGHEASPSKTMMTPYSVEK
TQTHAKQGCYVPQDRMMIISSERRKDIEDVQGYVRSQVQTMITKVSRGFC
HDLAQLILMLKTTFIGAWKMKRTIKEDAMYRDRKFDSNDEDGFTLIQIRN
PLALYVPIGWNGYGAHPAALNIVMTEEMYVDSIMISKLDEIMAPIRRIVH
DIPPCWNETQGDKRGLISATKMSFFSKMARPAVQAALSDPQIINLVEELP
LGEFSPGRISRTMMHSALLKESSARTLLSSGYELEYQKALNSWITQVSMR
LGEESGVISTSYAKLFDVYFEGELDGAPHMFPDQNLSPQFYIQKMMIGPR
VSSRVRNSYVDRIDVILRKDVVMRGFITANTILNVIEKLGTNHSVGDLVT
VFTLMNIETRVAEELAEYMTSEKIRFDALKLLKKGIAGDEFTMSLNVATQ
DFIDTYLAYPYQLTKTEVDAISLYCTQMIMLRAALGLPKKKMKIVVTDDA
KKRYKIRLQRFRTHVPKIKVLKKLIDPNRMTVRNLENQFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8w1o RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R520 E568 R573 Q814 M828 K1032 R1037
Binding residue
(residue number reindexed from 1)		R508 E556 R561 Q802 M816 K1020 R1025
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8w1o, PDBe:8w1o, PDBj:8w1o
PDBsum8w1o
PubMed38614100
UniProtW0G557

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