Structure of PDB 8uib Chain K Binding Site BS01

Receptor Information
>8uib Chain K (length=426) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYIT
RLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLE
DYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYA
GHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITEST
YATTRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMN
LKVPIYFSTGLTEKANHYYKLFIPWTNQKIRFKHIKAFDRAFADNPGPMV
VFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKL
EMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
EFLKQKIEQELRVNCYMPANGETVTL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8uib Chain K Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uib Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.
Resolution3.21 Å
Binding residue
(original residue number in PDB)		H68 H70 H157 D178
Binding residue
(residue number reindexed from 1)		H63 H65 H152 D173
Annotation score4
External links
PDB RCSB:8uib, PDBe:8uib, PDBj:8uib
PDBsum8uib
PubMed39032490
UniProtQ5TA45|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)

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