Structure of PDB 8rhk Chain K Binding Site BS01

Receptor Information

>8rhk Chain K (length=212) Species: 4932 (Saccharomyces cerevisiae)

TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAA
DCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTM
ICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSV
EDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV
KEEEGSFNNVIG

Ligand information

>8rhk Chain g (length=4) Species: 32630 (synthetic construct)

FLWG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rhk Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): T6 A25 T26 K38 G52 A54 S101 Y175
• Binding residue (residue number reindexed from 1): T1 A20 T21 K33 G47 A49 S96 Y170

Enzymatic activity

• Enzyme Commision number: 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

Molecular Function

• GO:0004298 threonine-type endopeptidase activity

Biological Process

• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005839 proteasome core complex

External links

• PDB: RCSB:8rhk, PDBe:8rhk, PDBj:8rhk
• PDBsum: 8rhk
• PubMed: 38628795
• UniProt: P30656|PSB5_YEAST Proteasome subunit beta type-5 (Gene Name=PRE2)