Structure of PDB 8pp6 Chain K Binding Site BS01

Receptor Information
>8pp6 Chain K (length=36) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFWDCSVCTFRNSAEAFKCSICDVRKGTSTRKPRIN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8pp6 Chain K Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8pp6 Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1.
Resolution3.18 Å
Binding residue
(original residue number in PDB)		C27 C30 C41
Binding residue
(residue number reindexed from 1)		C5 C8 C19
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003712 transcription coregulator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031519 PcG protein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pp6, PDBe:8pp6, PDBj:8pp6
PDBsum8pp6
PubMed38528151
UniProtQ8N488|RYBP_HUMAN RING1 and YY1-binding protein (Gene Name=RYBP)

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