Structure of PDB 8pk0 Chain K Binding Site BS01

Receptor Information
>8pk0 Chain K (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSFSRAPQQWATFARIWYLLDGKMQPPGKLAAMASIRLQGLHKPVYHALS
DCGDHVVIMNTRHIAFSGNKWEQKVYSSHTGYPGGFRQVTAAQLHLRDPV
AIVKLAIYGMLPKNLHRRTMMERLHLFPDEYIPEDILKNLVEELPQPRKI
PKRLDEYTQEEIDAFPRLWTPPEDYRL
Ligand information
>8pk0 Chain A (length=1423) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggcucuuuggacac
uaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggc
cuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaauccca
aacauauaacugaacuccucacacccaauuggaccaaucuaucacccuau
agaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcaua
agccugcgucagauuaaaacacugaacugacaauuaacagcccaauaucu
acaaucaaccaacaagucauuauuacccucacugucaacccaacacaggc
augcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuua
ccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagagg
caccgccugcuauauauauauauauauauauauauauauauuggcuccac
gaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgug
aggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuua
uuaaugcaaacagaaaccugcauuaaaaauuucgguuggggcgaccucgg
agcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaag
cgaacacucaauugauccaauaacuugaccaacggaacaaguuacccuag
ggacgcaauccuauucuagaguccauaucaacaauaggguuuuggaucag
gacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauua
aaguccuacgugaucugaguucagaccggaguaauccaggucgguuucua
ucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccua
cuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauac
ccaccccacccaagaacaggguu
<<<.......<<<<....................................
.<......>.........<.....<<.....>>....>........>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>......>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<...>>>>>>>>>..
.<<<......>>>....<<<.<<<...<..............<....<<<
.........>>>....>.......<<<......>>>..............
..........>...>>>>>>........>>>>>>...<<<<<......>>
>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<.
.......<<<<<..............>>>>>......<<<...<<<<...
....................>>>>.......>>>.....<<......>>.
>>>>.....>>>>..<<<<...<<<<<<<<.<<................<
<<<<<..<<<.........>>>...<<<<<<.............>>>>>>
....<<<...<<<<<<..>>>>>>.<<<<<<<..>>>>>>>.>>>....>
>.>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<..
...>>>>>.......<<..<<<........<<<<<.<<<<<<..<<<<<.
<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<
<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>
>.....>>.........<<<....>>>............>>>>..>>>>>
>>....<<<<<<<<<...<<.......>>...>>>>>>>>><<<<<.<<<
<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>...
..>>>>>..>...>>>>>.....<<<<<<<....>>>.>>>>........
>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...
<<<....>>>.>>>>>......<<<................>>>...>..
.......<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pk0 Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
Resolution3.03 Å
Binding residue
(original residue number in PDB)		G29 K30 L50 S68 K71 S78 H80 Y83 F87 A107 Y109 G110 M111 K114 N115 L116 H117 R118 Y176 R177
Binding residue
(residue number reindexed from 1)		G28 K29 L49 S67 K70 S77 H79 Y82 F86 A106 Y108 G109 M110 K113 N114 L115 H116 R117 Y175 R176
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0017148 negative regulation of translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8pk0, PDBe:8pk0, PDBj:8pk0
PDBsum8pk0
PubMed38042949
UniProtQ9BYD1|RM13_HUMAN Large ribosomal subunit protein uL13m (Gene Name=MRPL13)

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