Structure of PDB 8p03 Chain K Binding Site BS01

Receptor Information
>8p03 Chain K (length=206) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVGVRGG
NKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCI
VLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDE
RKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRK
IKARKG
Ligand information
>8p03 Chain 2 (length=1743) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcuacuuggauaacugugguaauuc
uagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgug
cauuuaucagaucaaaaccaacccggucggcggcuuuggugacucuagau
aaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaacg
ucugcccuaucaacuuucgaugguagucgccgugccuaccauggugacca
cgggugacggggaaucaggguucgauuccggagagggagccugagaaacg
gcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgac
ccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccu
guaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagg
gcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguauau
uaaaguugcugcaguuaaaaagcucguaguuggaucuuguggaggguucc
ccgccccuugccucucggcgccggcccgaagcguuuacuuugaaaaaauu
agaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaa
uggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaug
auuaagagggacggccgggggcauucguauugcgccgcuagaggugaaau
ucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaaugu
uuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccg
ucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauu
cccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgg
ggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcac
caccaggaguggagccugcggcuuaauuugacucaacacgggaaaccuca
cccggcccggacacggacaggauugacagauugauagcucuuucucgauu
cugugggugguggugcauggccguucuuaguugguggagcgauuugucug
guuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgac
ccccgagcggucggcgucccccaacuucuuagagggacaaguggcguuca
gccacccgagauugagcaauaacaggucugugaugcccuuagaugucggg
gcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccg
gcaggcgcggguaacccguugaaccccauucgugauggggaucggggauu
gcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagc
uugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuac
cgauuggaugguuuagugaggcccucggaucggcccgccggggugcccug
gcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaag
ucguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[........<<.....<<.<<<.....>
>>.>>......>>.........<<<...<<.<......>.>>...>>>.[
[..(((((......<<<<<<<<<<<.....>>>....<......>..)))
))......]]...<<<<.<<<......>>>.>>>>....]]]...}}...
.]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>.....
.>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........
>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<..
.>>>>..>>>......}}.......<<<<<..<<.<<<....>>>.>>..
.>>.>>>......<<..<...........>..>>.........<<<<<((
....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]
]]............{{.......{{...[[[.[[....<<<<.<<...>>
>>>>......<...<....<<..>>...>.>...<<<<<<.<.......<
<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>
.......[[....(((((((.....>>>>>>>>..)))))))...]]...
.]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>
>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>
.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>
>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<.
...>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....
<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<.
.<<..<<<<<..<<<.<<<<<<......<<........>>..........
<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>
>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<
<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<..
.<.<<<....>>>>...>....>>>>..>>>>..>.....<<<<<.....
>>>>>........>>>....>>>.>>>.....>>>>>>>>.....>>>>>
...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<.
...>>>>.>>>....>.........>>>.>>......<.....<<<<<..
........>>>>>.....>.....>>>>>.....<<<<<<<<.......>
>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<
<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<..>>>>>
>>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>
.>>...>.....<<<<<<<<<<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p03 N 6 -methyladenosine in 5' UTR does not promote translation initiation.
Resolution3.04 Å
Binding residue
(original residue number in PDB)
G2 I3 R5 H9 K10 R11 R12 K13 T14 Y21 K23 K24 R25 K26 Y27 L29 R31 A33 A34 R41 R42 H44 T45 R49 G50 K53 K54 Y55 R56 L58 N64 T73 K75 S86 K98 N99 R141 K143 K147 K148 A176 Q181 C182 R184 D186
Binding residue
(residue number reindexed from 1)
G1 I2 R4 H8 K9 R10 R11 K12 T13 Y20 K22 K23 R24 K25 Y26 L28 R30 A32 A33 R40 R41 H43 T44 R48 G49 K52 K53 Y54 R55 L57 N63 T72 K74 S85 K97 N98 R140 K142 K146 K147 A175 Q180 C181 R183 D185
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8p03, PDBe:8p03, PDBj:8p03
PDBsum8p03
PubMed38244546
UniProtG1TJW1|RS8_RABIT Small ribosomal subunit protein eS8 (Gene Name=RPS8)

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