Structure of PDB 8ovj Chain K Binding Site BS01

Receptor Information
>8ovj Chain K (length=170) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKSHYICAGRLVRILRGPRQDRVGVIVDIVDANRVLVENPEDAKMWRHVQ
NLKNVEPLKYCVSVSRNCSAKALKDALASSKALEKYAKTRTAARVEAKKA
CAVSTDFERYQLRVARRSRAHWARKVFDEKDAKTPVSWHKVALKKMLKKA
AKMDSTEGAKRRMQKAIAAR
Ligand information
>8ovj Chain 1 (length=1611) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucag
cggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaaga
gggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggc
acgugugguuggugcaggaguggcgaaauucaagcgaaaagcaaacccgu
ugcugaauacaacccuucaugugaguauugagccaaagaagguguuagcc
cauugagccauaaaccugagcgccucaugaacaagcgaguagcacuguuu
gggaaugcagugucaaguggcagguauuugucugccaaaguuaaauacag
aguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagc
acuuuggaaagagagugaaauagaaccugaagucgugacaaagacaaugg
aaguaccuccauuucaacggccagaaccagcccuacugcauuauccuguc
ggggaucaaaauccggcgggcaacgaagugcaagaaugggucuuggugaa
augagcggaguauuugugcugcgcacggcggccgcacgcacugguuucuu
cuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucu
ugaaacacggaccaaggagucaaacagacgcgcaagggaggagauaugcc
aguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugc
acacgucaaauccguuugauuugcccaacaccgaccggcccuccgugggu
ugcguuggagugugccuguuuggacccgaaagguggugaacuaugccuga
acaaggugaagcccggggaaacccagguggaggccuguagcgaugcugac
gugcaaaucgcucguaugauuuggguaucggagcgaaagacucaucgaac
caccuaguagcugguucacaucgaaguuucccucaggauagcuggugcua
guagaaguauugugcgguaaagcaaaugauuagaggcgaccuauucucaa
acuuuaaaugugcaaacaaaccggccuuagccaacugcaaggccggaaag
aaaagaauuagaggcaccaagugggccuucuucgguaagcggagcaggcg
augcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcuca
uucucgauacgugaaaaggguugguggauccaccggccccgaaaauggau
gacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcgg
aaacaaaggagaaaguguagcccuuccgauguagauguggccuggagguu
aggacgaagcuuauggcgugagccuaagauggaccggccucuagugcaga
ucuugguuggcguagcaaagaucuaacggagauauacucaacaugcaacg
uuggauacuggagcggggaaggauuucgugccaacggcacucguacacga
guuguucggaaacugagcacaacguuauaucguuuuguuaggaaagugaa
ggaacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaa
uugcauguggg
.......................<<<<<......<......>.......>
>>>.>.........<<....>>..<<<<<<......<<.....>>....>
>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>
>..<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......
>>>>.....<<........>>......>>>.<<.......((.....>>)
).....>>>>>...>>>..>>>>>.>>>>............<<<<<<<..
......>>>>>>>.....<<<<<........>>>>>..>>>.........
...........................<<....>>...............
.<<<<....>>>>..................................<<<
..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<<<..<<<<<<
<<<........>>>>>>>>>.....>>.>>>......>>>>..>>>>...
.....<<<<<.....<.<<<<.<<.<<<<.>>>>...>>.>.>>>..>..
>>>>>.....<<<<...>>>>>>....>>>>>>>>>>>..>>>.<<<<..
......>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<.....
...>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<..
.<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>
>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<
<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<.
.......>>>>>>>>....>>>>>>>>>...<<.......>>......>>
>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.
....<<...<<<<<<....<<<....<<<..<.<<<...>>>.>..>>>.
.>.>>....>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>....
.......>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>.
..<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<...
.....<...........<<<<<<<<<<..>>>>>>>>>>...........
))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<...
.......>>>>.........>>>>>>>>>....>>>>>..<.<<<<<<<<
........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>....
.>>>>>>..............<<<<<<<....................>>
>>>>>....................<<<<<....<<.....>>..>>>>>
....<<..........<<.<<<<<......>>>>...............<
<...>>......>.>>..........<<<<.........>>....>>.>>
...........
Receptor-Ligand Complex Structure
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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R17 P19 R20 N34 K45 W47 H49 N55
Binding residue
(residue number reindexed from 1)		R16 P18 R19 N33 K44 W46 H48 N54
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ4QBJ1

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