Structure of PDB 8jhf Chain K Binding Site BS01

Receptor Information
>8jhf Chain K (length=256) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTQEELKEVIERFKKDEH
LEKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILP
CNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGEND
FSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEP
GEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSPAPVINSKYGLRETD
KRLNRL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8jhf Chain K Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8jhf Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase
Resolution3.68 Å
Binding residue
(original residue number in PDB)		C321 C324
Binding residue
(residue number reindexed from 1)		C222 C225
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8jhf, PDBe:8jhf, PDBj:8jhf
PDBsum8jhf
PubMed38052811
UniProtQ4FZB7|KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (Gene Name=KMT5B)

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