Structure of PDB 8ham Chain K Binding Site BS01

Receptor Information
>8ham Chain K (length=517) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEELRQALMPTLEALYRQDPESLPFRQPVDPIPDYFDIVKNPMDLSTIKR
KLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEID
PVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKC
FTEISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVC
DNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVF
VRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVC
FFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYL
EYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLD
KAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKDLSQ
KLYATMEKHKEVFFVIHLHDPDPLLSCDLMDGRDAFLTLARDKHWEFSSL
RRSKWSTLCMLVELHTQ
Ligand information
>8ham Chain I (length=165) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ttaccgccatcaatatccacctgcagattctaccaaaagtgtatttggaa
actgctccatcaaaaggcatgttcagctgaattcagctgaacatgccttt
tgatggagcagtttccaaatacacttttggtagaatctgcaggtggatat
tgatggcggtaacgg
Receptor-Ligand Complex Structure
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PDB8ham Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		R1173 K1176 K1492 K1495 R1498 E1528 D1529
Binding residue
(residue number reindexed from 1)		R83 K86 K384 K387 R390 E420 D421
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8ham, PDBe:8ham, PDBj:8ham
PDBsum8ham
PubMed37460559
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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