Structure of PDB 8hal Chain K Binding Site BS01

Receptor Information
>8hal Chain K (length=513) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDL
STIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVF
EQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQHFCE
KCFTEKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVC
DNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVF
VRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVC
FFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYL
EYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLD
KAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKEKLY
ATMEKHKEVFFVIHLHLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWST
LCMLVELHTQGQD
Ligand information
>8hal Chain I (length=151) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccatcaatatccacctgcagattctaccaaaagtgtatttggaaactgct
ccatcaaaaggcatgttcagctgaattcagctgaacatgccttttgatgg
agcagtttccaaatacacttttggtagaatctgcaggtggatattgatgg
c
Receptor-Ligand Complex Structure
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PDB8hal Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		T1171 S1172 R1173 K1176 F1177
Binding residue
(residue number reindexed from 1)		T86 S87 R88 K91 F92
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8hal, PDBe:8hal, PDBj:8hal
PDBsum8hal
PubMed37460559
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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