Structure of PDB 8haj Chain K Binding Site BS01

Receptor Information
>8haj Chain K (length=533) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDL
STIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVF
EQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYH
FCEKCFNEIQGESNKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHE
IIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQ
NHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAF
EEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAV
YHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRL
QEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVL
EESIKENDLSQKLYATMEKHKEVFFVIRLIIVDPDPLIPCDLMDGRDAFL
TLARDKHLEFSSLRRAQWSTMCMLVELHTQSQD
Ligand information
>8haj Chain I (length=164) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ttaccgccatcaatatccacctgcagattctaccaaaagtgtatttggaa
actgctccatcaaaaggcatgttcagctgaattcagctgaacatgccttt
tgatggagcagtttccaaatacacttttggtagaatctgcaggtggatat
tgatggcggtaacg
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8haj Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		K1134 K1140 K1488 T1491 E1492 D1493 R1494
Binding residue
(residue number reindexed from 1)		K85 K91 K425 T428 E429 D430 R431
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8haj, PDBe:8haj, PDBj:8haj
PDBsum8haj
PubMed37460559
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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