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Receptor Information

>8hai Chain K (length=533) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLS
TIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFE
QEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHF
CEKCSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLK
KSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVH
ASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMH
VQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKK
LGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSE
RIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQENDLS
QKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFL
TLARDKHLEFSSLRRAQWSTMCMLVELHTQSQD

>8hai Chain J (length=147) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

catcaatatccacctgcagattctaccaaaagtgtatttggaaactgctc
catcaaaaggcatgttcagctgaattcagctgaacatgccttttgatgga
gcagtttccaaatacacttttggtagaatctgcaggtggatattgat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8hai Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Resolution	4.7 Å
Binding residue (original residue number in PDB)	R1133 K1134
Binding residue (residue number reindexed from 1)	R83 K84

Enzyme Commision number

2.3.1.-
2.3.1.48: histone acetyltransferase.

	Molecular Function
GO:0004402	histone acetyltransferase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

PDB	RCSB:8hai, PDBe:8hai, PDBj:8hai
PDBsum	8hai
PubMed	37460559
UniProt	Q09472\|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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Structure of PDB 8hai Chain K Binding Site BS01