Structure of PDB 8gui Chain K Binding Site BS01

Receptor Information
>8gui Chain K (length=72) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTR
QRKCPKCNAAFGANDFHRIYIG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8gui Chain K Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8gui Structure of the human Bre1 complex bound to the nucleosome
Resolution2.81 Å
Binding residue
(original residue number in PDB)		C937 H939 C957 C960
Binding residue
(residue number reindexed from 1)		C34 H36 C54 C57
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003730 mRNA 3'-UTR binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
GO:0140850 histone H2B C-terminal K residue ubiquitin ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0030336 negative regulation of cell migration
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0033503 HULC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gui, PDBe:8gui, PDBj:8gui
PDBsum8gui
PubMed38519511
UniProtQ5VTR2|BRE1A_HUMAN E3 ubiquitin-protein ligase BRE1A (Gene Name=RNF20)

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