Structure of PDB 8dga Chain K Binding Site BS01

Receptor Information

>8dga Chain K (length=182) Species: 7227 (Drosophila melanogaster)

AMKTPVSILQELLSRRGITPGYELVQIEGAIHEPTFRFRVSFKDKDTPFT
AMGAGRSKKEAKHAAARALIDKLITQHSNKVSQFHKTLKNATGKKLLKLQ
KTCLKNNKIDYIKLLGEIATENQFEVTYVDIEEKTFSGQFQCLVQLSTLP
VGVCHGSGPTAADAQRHAAQNALEYLKIMTKK

Ligand information

>8dga Chain E (length=19)

gagguaguagguuguauag

...................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8dga Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB.
• Resolution: 3.73 Å
• Binding residue (original residue number in PDB): K134 T135 H163 K190
• Binding residue (residue number reindexed from 1): K3 T4 H32 K59

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003725 double-stranded RNA binding
• GO:0005515 protein binding
• GO:0035197 siRNA binding
• GO:1905172 RISC complex binding

Biological Process

• GO:0007417 central nervous system development
• GO:0009047 dosage compensation by hyperactivation of X chromosome
• GO:0010468 regulation of gene expression
• GO:0010586 miRNA metabolic process
• GO:0030422 siRNA processing
• GO:0030718 germ-line stem cell population maintenance
• GO:0031047 regulatory ncRNA-mediated gene silencing
• GO:0031054 pre-miRNA processing
• GO:0048132 female germ-line stem cell asymmetric division
• GO:0070920 regulation of regulatory ncRNA processing
• GO:0070922 RISC complex assembly

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0016442 RISC complex
• GO:0070578 RISC-loading complex

External links

• PDB: RCSB:8dga, PDBe:8dga, PDBj:8dga
• PDBsum: 8dga
• PubMed: 36182693
• UniProt: Q9VJY9|LOQS_DROME Protein Loquacious (Gene Name=loqs)