Structure of PDB 8cbj Chain K Binding Site BS01

Receptor Information
>8cbj Chain K (length=99) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDILARHRKENKDLQNKITGMKKQATKSKRKEVNSKCLDLQDKLKTKQE
NEIRDWKIANVTPEKLLEQLSNRQKERLAKRDAAIAKMKEEAALEASKQ
Ligand information
>8cbj Chain 2 (length=1767) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucugguugauccugccaguagucauaugcuugucucaaagauuaagcca
ugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucau
uaaaucaguuaucguuuauuugauaguuacaugguauaacugugguaauu
cuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuu
auuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacu
uuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcc
cuaucaacuuucgaugguaggauaguggccuaccaugguuucaacgggua
acggggaauaaggguucgauuccggagagggagccugagaaacggcuacc
acauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucaggg
agguagugacaauaaauaacgauacagggcccauucgggucuuguaauug
gaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaaguc
uggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguu
guugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucg
gauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcuc
uuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcagg
cguauugcucgaauauauuagcauggaauaauagaauaggacguuugguu
cuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgg
gggcaucaguauucaauugucagaggugaaauucuuggauuuauugaaga
cuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacg
aaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaa
acuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggca
ccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaag
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacggggaaacucaccagguccagacacaauaaggauug
acagauugagagcucuuucuugauuuugugggugguggugcauggccguu
cuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagacc
uuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuag
agggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucug
ugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagcca
gcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccguc
gugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccua
guaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguaca
caccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggauc
ugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaac
uuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaac
cugcggaaggaucauua
..<<<<<...[[[[>>>>>[[[[.((((((................[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[..{{..{{....[[[..........<<....<<.<<<.....
>>>.>>.....>>.........<<<<<..<<....>>..>>>>>[...((
((((......<<<<<<<<<<<....>>>..............))))))..
...]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<
<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>..
.<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>
.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>.
.>>>...............<<<<<<<<<<<<<....>>>>>>>>>>.>>>
......<<..<...........>..>>.........<<<<<((......<
<<<.........)).........>>>>.>>>>>..))))))]]]].....
....[[[{{.......{{...[[[.{{....<<<<<<.<<<<<....<..
>....>>>>>.>>>>>>.....<<<<<.<..<<..<<<<<.....>>>>>
..>>..>.>>>>>....<<<<<.<<.......<<...<.......>..<<
<.....>>>....>>......>>.>>..>>>.........[[[..(((((
(((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<..
.<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..
>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}...
...<<<<<<<...<...<<<<.........>>>>...>>>>>>>>.....
.....<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..
>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>
>>>....>>>..]]]]....<<<.<<<<<<<..<<.<<<<<<..<<<.<<
<<<<......<<.>>..((......<<<<<.<....<<<<<........<
<.<<<........>>>.>>......>>>>>......<<<.<<<<<<<<<<
....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<
<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>
.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>>.>
>>..>>>.......>.>>>>>...>>.>>>>.>>>.....<<<<<<<...
...<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>
......<....<<<<<<..........>>>>>>....>.....>>>>>>.
...<<<<<<<<...))..>>>>>>>>......>>...>>>>>>>>>>...
.<<<...<<.<..<<<<.<<..<<<<<<<<<<.<<<..<.<<..<...<<
<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>
>.>>>>>>>>>>.>>.>>>>...>.>>......>>><<<<<<<<<....>
>>>>>>>>.........
Receptor-Ligand Complex Structure
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PDB8cbj Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		K30 G33 K36 T39 K40 S41 K42 Q122
Binding residue
(residue number reindexed from 1)		K18 G21 K24 T27 K28 S29 K30 Q74
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0008150 biological_process
GO:0016579 protein deubiquitination
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8cbj, PDBe:8cbj, PDBj:8cbj
PDBsum8cbj
PubMed37169754
UniProtP38747|OTU2_YEAST OTU domain-containing protein 2 (Gene Name=OTU2)

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