Structure of PDB 7zm7 Chain K Binding Site BS01

Receptor Information

>7zm7 Chain K (length=182) Species: 759272 (Thermochaetoides thermophila DSM 1495)

VEPYPGYELRKSLRKEVPLPSQEGTKGLVQYALTTLDIITNWARQGSFWP
MTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMA
PALRQVYDQMPDPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVP
GCPPTSEALMYGIFQLQRKMRNTKITRMWYRK

Ligand information

• Ligand ID: SF4
• InChI: InChI=1S/4Fe.4S
• InChIKey: LJBDFODJNLIPKO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: [S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
  CACTVS 3.385: S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
• Formula: Fe4 S4
• Name: IRON/SULFUR CLUSTER
• PDB chain: 7zm7 Chain K Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7zm7 Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum.
• Resolution: 2.77 Å
• Binding residue (original residue number in PDB): C105 C106 C170 C200 P201
• Binding residue (residue number reindexed from 1): C57 C58 C122 C152 P153
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport
• GO:0032981 mitochondrial respiratory chain complex I assembly

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:7zm7, PDBe:7zm7, PDBj:7zm7
• PDBsum: 7zm7
• PubMed: 36427319
• UniProt: G0S9I6