Structure of PDB 7ycx Chain K Binding Site BS01

Receptor Information
>7ycx Chain K (length=590) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYIT
QNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPI
LLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKA
YYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLIT
ESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILL
ETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEF
KHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPG
YCVQGTVGHKILSGQRKLEVLEVKMQVEYMSFSAHADAKGIMQLVGQAEP
ESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGIS
LGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEH
QLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVL
LQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQ
Ligand information
>7ycx Chain c (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauaaccggagagggaacccacu
.......................
Receptor-Ligand Complex Structure
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PDB7ycx Structural basis of INTAC-regulated transcription.
Resolution4.18 Å
Binding residue
(original residue number in PDB)		M37 H70 L71 D106 Y107 I110 H157 F240 R310 T324 P325 H329 A330 Q332 Y353 H392
Binding residue
(residue number reindexed from 1)		M35 H68 L69 D104 Y105 I108 H155 F238 R308 T322 P323 H327 A328 Q330 Y351 H385
Enzymatic activity
Enzyme Commision number 3.1.27.-
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032039 integrator complex
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ycx, PDBe:7ycx, PDBj:7ycx
PDBsum7ycx
PubMed36869814
UniProtQ5TA45|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)

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