Structure of PDB 7x8x Chain K Binding Site BS01

Receptor Information

>7x8x Chain K (length=175) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDISLYINS
PGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALP
HARILMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQPIERIE
ADSDRDRWFTAAEALEYGFVDHIIT

Ligand information

>7x8x Chain c (length=3) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cLL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7x8x structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease
Resolution	3.24 Å
Binding residue (original residue number in PDB)	G69 S70 I71 S98 M99 H123 P125 L126 F143
Binding residue (residue number reindexed from 1)	G53 S54 I55 S82 M83 H107 P109 L110 F127

Enzymatic activity

Enzyme Commision number

3.4.21.92: endopeptidase Clp.

Gene Ontology

	Molecular Function
GO:0004176	ATP-dependent peptidase activity
GO:0004252	serine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:7x8x, PDBe:7x8x, PDBj:7x8x
PDBsum	7x8x
PubMed
UniProt	P9WPC5\|CLPP1_MYCTU ATP-dependent Clp protease proteolytic subunit 1 (Gene Name=clpP1)

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