Structure of PDB 7wld Chain K Binding Site BS01

Receptor Information

>7wld Chain K (length=331) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RSGHTNNWAVLVCTSRFWFNYRHVANTLSVYRSVKRLGIPDSHIVLMLAD
DMACNPRNPKPATVFSHKNMELNVYGDDVEVDYRSYEVTVENFLRVLTGR
IPPSTPRSKRLLSDDRSNILIYMTGHGGNGFLKFQDSEEITNIELADAFE
QMWQKRRYNELLFIIDTCQGASMYERFYSPNIMALASSQVGEDSLSHQPD
PAIGVHLMDRYTFYVLEFLEEINPASQTNMNDLFQVCPKSLCVSTPGHRT
DLFQRDPKNVLITDFFGSVRKVEITTETIKLQQMEPLKYAEQLPVAQIIH
QKPKLKDWHPPGGFILGLWALIIMVFFKTYG

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

7wld Chain K Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7wld Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins.
Resolution	2.53 Å
Binding residue (original residue number in PDB)	D79 I82 D120
Binding residue (residue number reindexed from 1)	D41 I44 D82
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.-.-.-

Gene Ontology

	Molecular Function
GO:0003923	GPI-anchor transamidase activity
GO:0008233	peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0008218	bioluminescence
GO:0016255	attachment of GPI anchor to protein

	Cellular Component
GO:0042765	GPI-anchor transamidase complex

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External links

PDB	RCSB:7wld, PDBe:7wld, PDBj:7wld
PDBsum	7wld
PubMed	35551457
UniProt	Q92643\|GPI8_HUMAN GPI-anchor transamidase (Gene Name=PIGK)

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