Structure of PDB 7w72 Chain K Binding Site BS01

Receptor Information
>7w72 Chain K (length=330) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSGHTNNWAVLVCTSRFWFNYRHVANTLSVYRSVKRLGIPDSHIVLMLAD
DMACNPRNPKPATVFSHKNMELNVYGDDVEVDYRSYEVTVENFLRVLTGR
IPPSTPRSKRLLSDDRSNILIYMTGHGGNGFLKFQDSEEITNIELADAFE
QMWQKRRYNELLFIIDTCQGASMYERFYSPNIMALASSQVGEDSLSHQPD
PAIGVHLMDRYTFYVLEFLEEINPASQTNMNDLFQVCPKSLCVSTPGHRT
DLFQRDPKNVLITDFFGSVRKVEITTETIKLQQMEPLKYAEQLPVAQIIH
QKPKLKDWHPPGGFILGLWALIIMVFFKTY
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7w72 Chain K Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7w72 Structure of human glycosylphosphatidylinositol transamidase.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D79 I82 D120
Binding residue
(residue number reindexed from 1)		D41 I44 D82
Annotation score4
Enzymatic activity
Enzyme Commision number 3.-.-.-
Gene Ontology
Molecular Function
GO:0003923 GPI-anchor transamidase activity
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0042765 GPI-anchor transamidase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w72, PDBe:7w72, PDBj:7w72
PDBsum7w72
PubMed35165458
UniProtQ92643|GPI8_HUMAN GPI-anchor transamidase (Gene Name=PIGK)

[Back to BioLiP]